Suppose we have arrived at the expression
$$6{n+1 \choose 4} + 6{n+1 \choose 3} + {n+1 \choose 2},$$
and we remain in a combinatorial mood, not an algebraic one. Then we might work a little harder and give a bijective argument.
From a group of $n+1$ boys and $n+1$ girls, we can choose $2$ boys and $2$ girls (a pair of pairs) in
$$\binom{n+1}{2}^2$$
ways. We will count the number of pairs of pairs in another way.
Let the boys be called $b_0,b_1,\dots,b_n$, and the girls $g_0, g_1,\dots,g_n$. If $2$ boys and $2$ girls are chosen they either (a) share no number or (b) share $1$ number or (c) share $2$ numbers.
(a) The pairs of pairs that share no number can be chosen as follows. Choose $4$ numbers from the set $\{0,1,\dots,n\}$. Then choose $2$ of the $4$ numbers, and select the boys with these $2$ numbers, and the girls with the remaining $2$ numbers. The choosing of $4$ numbers can be done in $\binom{n+1}{4}$ ways, and the choosing of $2$ from $4$ can be done in $\binom{4}{2}=6$ ways, for a total of
$$6\binom{n+1}{4}.$$
(b) The pairs of pairs that share exactly one number can be chosen as follows. Choose $3$ numbers from $\{0,1,\dots,n\}$. Choose $1$ of these $3$ numbers to be the "duplicated" number (boy and girl), then select the boy who has $1$ of the remaining numbers, and the girl with the other. The choosing of the $3$ numbers can be done in $\binom{n+1}{3}$ ways. For each of these, we can choose the duplicated number in $3$ ways, and decide which of the remaining numbers will be a boy number in $2$ ways, for a total of
$$(3)(2)\binom{n+1}{3}.$$
(c) Finally, we count the pairs of pairs that share two numbers.
All we need to do is to choose these $2$ numbers, and the rest is determined, so the number of type (c) pairs of pairs is
$$\binom{n+1}{2}.$$
Add up.