To my knowledge, given an arbitrary integral domain, there is no "general" method to figure out whether it is a Euclidean domain.
To expand a bit on JessicaB's comment, though, we can completely determine which of the rings of the form $$\Bbb Z[\sqrt{-n}]:=\{a+b\sqrt{-n}:a,b\in\Bbb Z\}$$ are Euclidean domains (where $n$ is some positive integer). Let me outline how one might do it.
Given a positive integer $n$, we define $\rho_n$ from $\Bbb Z[\sqrt{-n}]$ to the nonnegative integers by $$\rho_n(a+b\sqrt{-n}):=a^2+b^2n.$$ This function will tell us important things about the ring. Some useful facts to prove are:
(A) $\rho_n$ is a multiplicative function--that is, $\rho_n(x\cdot y)=\rho_n(x)\cdot\rho_n(y)$.
(B) $x\in\Bbb Z[\sqrt{-n}]$ is a unit of $\Bbb Z[\sqrt{-n}]$ if and only if $\rho_n(x)=1$, and $x=0$ if and only if $\rho_n(x)=0$.
(C) If $x,y\in\Bbb Z[\sqrt{-n}]$ are associates (that is, differ by multiplication by a unit), then $\rho_n(x)=\rho_n(y)$. (The converse doesn't hold, though. Consider $1\pm2\sqrt{-n}$.)
(D) If $x\in\Bbb Z[\sqrt{-n}]$ is nonzero and not a unit, then $x=x_1\cdots x_k$, where each $x_j$ is irreducible in $\Bbb Z[\sqrt{-n}]$. (That is, we have existence, though not necessarily uniqueness, of irreducible factorizations.)
(E) If $n\geq 2$, then $\sqrt{-n}$ is irreducible in $\Bbb Z[\sqrt{-n}]$.
(F) If $n\geq 3$, then $2$ is irreducible in $\Bbb Z[\sqrt{-n}]$.
Having these handy facts in our arsenal, it isn't too difficult to prove the following two results:
($1$) If $n=1$ or $n=2$, then $\Bbb Z[\sqrt{-n}]$ is a Euclidean domain, with Euclidean function $\rho_n$.
($2$) If $n\geq 3$ (whether $n$ is square-free or not), then $\Bbb Z[\sqrt{-n}]$ is not a UFD, so not a Euclidean domain. [As JessicaB pointed out, you need only show that $2$ is not prime in $\Bbb Z[\sqrt{-n}]$. You may want to do two cases, for $n$ odd and $n$ even.]