In many prior answers you can find explanations motivating the definition of the equivalence relation in the common pair-based normal form construction of localizations. But this does not provide immediate intuition for the alternative presentation-based construction of the fraction ring (localization) $\rm\,S^{-1} R\,$ as, conceptually, the universal way of adjoining inverses of $\rm\,S\,$ to $\rm\,R\,$ via $\rm\,S^{-1} R = R[x_i]/(s_i x_i - 1),\,$ as in your special case. This presentation-based approach allows us to exploit to the hilt the universal properties of quotient rings and polynomial rings to quickly and easily construct and derive basic properties of localizations (avoiding the many tedious verifications always "left for the reader" in the more commonly pair=based normal-forms approach).
In this presentation-based approach there is no need to unintuitively massage an equivalence relation to account for annihilated elements. Rather we can directly compute what is annihilated by a simple (widely-overlooked) trick: $ $ if $\rm\,r\in R\,$ lies in the kernel of $\rm\, R\to S^{-1} R = R[x]/(1\!-\!sx),\,$ then $\rm\,r \in (1\!-\!sx)R[x]\,\Rightarrow\, r = (1\!-\!sx)f(x)\,$ so by comparing coefficients we obtain
$\quad \begin{eqnarray}\rm n = deg\, f\quad and\quad r &=&\rm (1\!-\!sx)\,f(x) &\Rightarrow&\ \rm f(0) = r\qquad\,\ \ \ via\ \ coef\ x^0 \\
\rm\Rightarrow\ (1\!+\!sx\!+\dots+\!(sx)^n)\, r &=&\rm (1\!-\!(sx)^{n+1})\, f(x) &\Rightarrow&\ \rm f(0)\,s^{n+1}\! = 0\quad via\ \ coef\ x^{n+1} \\
& & &\Rightarrow&\ \rm\ \ \,\bbox[5px,border:1px solid #c00]{r\ s^{n+1} = 0}
\end{eqnarray}$
As Xam wrote in his answer, this immediately yields the result that you seek.
and using the above proof requires no prior knowledge of the (pair-based) localization construction.
If you introspect on the construction used in the pair-based approach you will find that it boils down to choosing $\rm\color{#0a0}{constant}$ normal-form reps of equivalence classes in the above quotient rings
$$\rm f(x) = s^n f(x)/s^n = s^n(f_n x^n+\cdots +f_1 x+ f_0)/s^n = (f_n+ f_1 s^{n-1} + f_0 s^n)/s^n = \color{#0a0}{r/s^n},\ r\in R$$
analogous to how Hamilton's pair-based construction of $\,\Bbb C = \Bbb R[x]/(x^2+1)$ chooses $\rm\color{#0a0}{least\ degree}$ (= linear) normal form reps $\rm\,a+bx\,$ of polynomials $\rm \bmod\, x^2+1\,$ with the ring operations and congruence transported to the pair normal form reps, e.g. transported multiplication of pairs is
$\rm\begin{eqnarray}\rm (a,\ b) &&\rm (c,\ d) &\!\!=&\rm (ac\!\color{#000}{\bf -}\!bd,\quad\ \ ad\!+\!bc)\\[.2em]
\rm i.e.\ \bmod{\color{#c00}{\,x^2\!+1}}\!:\ \ \color{#c00}{x^2\equiv -1}\ \,\Rightarrow\,\ (a\! +\! b\color{#c00}x)&&\rm(c\! +\! d\color{#c00}{ x})\, &\!\!\!\rm\,\equiv&\rm (ac\!\color{#c00}{\bf -}\!bd) + (ad\!+\!bc)\, x\\[.3em]
\rm i.e.\quad\, (a\! +\! b{\it i}\,)&&\rm(c\! +\! d {\it i}\,)\, &\!\! =\,&\rm (ac\!\color{#000}{\bf -}\!bd) + (ad\!+\!bc)\,{\it i}\end{eqnarray}$
The pair-based localization construction is precisely analogous, i.e. the construction transports the ring operations and congruence to normal form reps of the equivalence classes of the quotient rings. When viewed in this way, the equivalence relation imposed on the fraction pair reps $\rm\,(r,s^n)\,$ arises naturally and no longer seems contrived.
This is a protoypical example of ubiquitous techniques employed in normal form computation in quotient objects, so it is well-worth the effort to study it carefully.
For further discussion (including literature references) see this answer.