Questions tagged [synthesis]

Synthesis is a purposeful execution of chemical reactions to obtain the desired product. Applies to long and complex natural product syntheses as much as to short one or two-step syntheses. This also covers synthetic problem sets and retrosynthetic analyses.

Synthesis is a purposeful execution of chemical reactions to obtain the desired product.

Syntheses come in all tastes and sizes, from a single reaction to tedious, multi-step processes, involving purification of numerous intermediates. Almost the entire division of natural product chemistry is devoted to the stereoselective synthesis of the vast natural product library.

Typically, long and complex syntheses are preceded by retrosynthetic analyses, deciding which steps to perform in which order, where to cut the molecule apart into fragments and which carbon-carbon bonds need to be formed during this process.

Applicability of the synthesis tag:

  • should be applied to all questions relating to a synthesis, from short 2 step sequences, to long 50 step total syntheses
    • The tag may be applied to both published syntheses, or hypothetical ones
    • The tag may be applied in both the forward sense (syntheses), or the reverse sense (retrosynthesis).
    • The tag should not be applied to simple reactions such as the formation of hydrogen by acidic oxidation of metals.
    • The tag should not be applied to questions.
  • Depending on the nature of the synthesis, or should also be applied to the question to further define the area of synthesis being discussed.
  • Additional tags such as or may also be applied, if the question is asking about a specific aspect of the synthesis, e.g. 'why does step 5 give the 1,2-anti stereochemistry from the aldol reaction'

Related tags:

The following tags are related to , with multiple questions on chemistry.se already tagged with one of more of the following which may be useful as additional tags on questions identified as being related to organic chemistry:

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Is it possible that diamond can be grown from aqueous solutions?

Assume a cubic diamond crystal with hydrogen-terminated surface bonds. The terminating hydrogen atoms will form pairs that are geometrically close together in alternating diagonal pairs (think of the rectangles on corrugated walking steel). Next,…
Terry Bollinger
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Chemical synthesis via 3D printing?

I happened to stumble upon this Nature Chemistry article today. It claims that [...] use a 3D printer to initiate chemical reactions by printing the reagents directly into a 3D reactionware matrix, and so put reactionware design, construction and…
LanceLafontaine
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How can one synthesise a conjugated alkyne chain?

Let's take the conjugated alkyne chain (e) below, taken from Wikipedia: How would one typically go about synthesising such a conjugated chain with a series of alkyne functions?
F'x
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Adenine precursor synthesis

I am currently exploring the synthesis of xRNA, which contains benzo-expanded purine and pyrimidines. I have found this paper which deals with exactly this subject, and provides the following synthetic pathway for the xA…
LanceLafontaine
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Methyl Iodide synthesis

I was trying to determine whether I could synthesize methyl iodide by combining methanol, potassium iodide and sulphuric acid together... The way I see it, the sulphuric acid will protonate the OH instead of the I forming a very stable leaving group…
jakerz
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Can I synthesize potassium hydroxide from readily available materials?

Where I live, KOH is not readily available and is cost prohibitive to ship. A number of other materials are available, however. I have read similar questions and their answers here, but most are too general or too specific for me to understand. I…
Jared Brandt
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Viability of proposed carbon-carbon bond-forming reaction

Here is my proposed synthetic pathway to make propanoic acid from bromoethane: $\ce{CH3-CH2Br ->[\ce{KCN(aq)}][\text{heat}] CH3-CH2-C#N}$ $\ce{CH3-CH2-C#N ->[\ce{KOH(aq)}][\text{heat under reflux}] CH3-CH2-COOH + NH3\uparrow}$ I have some…
DHMO
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How would you Synthesise LY-293,284?

How would I synthesise LY-293,284? Figure 1: LY-293,284 I have satisfied the conditions at the page Should we allow Synthesis questions subject to the six constraints listed below? so please don't just write off this question and close it. The…
Josh Pinto
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Hydrolysis of nitriles: Amide vs Carboxylic acid

I was recently studying the preparation of amides,and one of the methods listed was acid hydrolysis of a nitrile. Up until now I thought acid hydrolysis of nitriles yielded carboxylic acids. How are the methods to get amides and acids different? I…
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Zinin Reduction of 1,3-dinitrobenzene

Remember asking my chemistry teacher this question in 1979/80: in the reduction of 1,3-dinitrobenzene with hydrogen sulphide/ aqueous ammonia, why is only one nitro group reduced?. He said that the reaction must be driven by the electon-depleted…
tony
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Is this amide compound electrophilic enough to be attacked by a cyclopentadiene in base?

I am trying to make a fulvene molecule with dimethylamino and phenyl substituents. My worry is that the amide group donates electron density into the carbonyl carbon making it less electrophilic.
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Is this structure make-able?

I was wondering if it would be possible to make this chemical?
ShaneJf
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Is it possible to create a 100% identical copy of a chemical?

Is it possible to create a 100% identical copy of a chemical? For example, a 100% identical copy of vitamin A would have the same shape, the same formula, and the same structure.
Konrad
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TMSBr and 2,4,6 Collidin in Acetonitrile leads to white precipitate

I want to hydrolyse a phosphonic acid ester with TMSBr. I think this reaction works only with the addition of base. Without base, the product in my specific case is prone to deterioation due to acid sensitivity. In the literature I found, that…
raptorlane
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Alternative synthesis for LK-99 proposed room-temperature superconductor

This is probably not the best place to post this, but I'm posting in case it might reach the right people who could give this a try. The current synthesis for the proposed LK-99 superconductor is a multi-step process that goes through a sulfate…
MichaelK
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