In this neat answer by Markus Heinrich, it is shown that twirling an arbitrary quantum channel $\Lambda$ over the unitary group $U(d)$ yields a depolarizing channel $\tilde{\Lambda}$ given by $$ \tilde{\Lambda}(M) = \Pi_{U(d)}(\Lambda)(M) = (1-p)\mathrm{Tr}(M) \frac{I}{d} + p M, $$ where $M$ is a linear operator on the Hilbert space (and $p$ is some function of $\Lambda$, $M$, and $d$).
1st question: Is this "unitary twirling operation" considered something physically realizable? For example, it often seems to be the case that the depolarizing channel is used in simulations and calculations, etc; is this because if we are given an arbitrary channel we can simply start any algorithm by unitary-twirling in some physical manner and therefore we may as well assume we started with the depolarizing channel to begin with? The comment by Norbert Schuch to this answer seems to suggest that the answer is yes, but maybe someone can provide more details?
2nd question: As Heinrich points out in his answer, one can replace $U(d)$ by any group $G$ and take the "$G$-twirl" of a channel instead of the unitary twirl. Is the $G$-twirl operation consider something physical?