Here's a more general equality, and the combinatorial reason for this type of equality. Let $n\geq k \geq r$ be non-negative integers. Then:
$$\binom{n}{r} \binom{n-r}{k-r}=\binom{k}{r}\binom{n}{k}.$$
Proofs:
1) Consider the set $[1,n]=\{1, \cdots, n\}.$ Let
$${\mathcal S}=\{(S,T)\subset [1,n]\times[1,n] \mbox{ s.t. } |S|=k, |T|=r, T \subset S\}.$$
One may choose first $S$ and then its subset $T$, which yields the count
$$\binom{n}{k} \binom{k}{r},$$ or alternatively choose $T$ first, and then choose $S\setminus T$, which yields:
$$\binom{n}{r} \binom{n-r}{k-r}.$$
2) Consider the expression $\frac{1}{r!}\left(\frac{d}{dx}\right)^r(1+x)^n.$ Differentiating the Newton binomial termwise yields
$$\sum_{k\geq r} \binom{n}{k} \binom{k}{r} x^{k-r},$$
whereas, if we differentiate without expanding, we obtain
$$\frac{1}{r!}\left(\frac{d}{dx}\right)^r(1+x)^n=\binom{n}{r} (1+x)^{n-r},$$
which in turn yields (our index will run from $r$ to $n$):
$$\sum_{k\geq r} \binom{n}{r} \binom{n-r}{k-r} x^{k-r},$$
and the identity follows.
Of course, one can simply operate the factorials, though that one is slightly less exciting :)
The genesis of the formula becomes apparent with any of the above proofs.