Since $\binom{2n}{k}$ is the number of subsets of $\{1,\ldots,2n\}$ with exactly $k$-elements, $$\sum_{k=0}^{n} \binom{2n}{2k} = \binom{2n}{0} + \binom{2n}{2} + \binom{2n}{4} + \ldots + \binom{2n}{2n}$$ is the number of subsets of $\{1,2,\ldots,2n\}$ which have an even number of elements.
For any nonempty, finite set $X$, exactly half the subsets of $X$ have even cardinality, and the other half have odd cardinality. To see this, fix some element $p \in X$. Define a function $f : \mathscr{P}(X) \to \mathscr{P}(X)$ by
$$ f(A) = \begin{cases}
A \cup \{p\} & \text{ if } p \notin A \\
A \setminus \{p\} & \text{ if } p \in A \\
\end{cases} $$
The effect of $f$ is to toggle whether or not $p$ belongs to a subset. Note $f$ is a bijection. In fact, $f \circ f = \mathrm{id}$, so $f$ is its own inverse. Also, the cardinality of $f(A)$ is always $1$ away from the cardinality of $A$. So, $f$ maps the even-cardinality subsets to the odd-cardinality subsets, and vice versa.
In conclusion, one has
$$ \sum_{k=0}^{n} \binom{2n}{2k} = \frac{\text{the number of subsets of $\{1,2,\ldots,2n\}$}}{2} = \frac{2^{2n}}{2} = 2^{2n-1}$$