It is Exercise 4.3.2 in the book An Invitation to Algebraic Geometry.
Show that the ring $\mathcal{O}_V(U)$ of regular functions on the punctured plane $U=\mathbb{A}^2\backslash\{(0,0)\}$ is the polynomial ring $\mathbb{C}[x,y]$ (where I think $V=\mathbb{A}^2$). Conclude that this quasi-projective variety is not affine.
My try is as follows.
Obviously we have $\mathbb{C}[x,y]\subset \mathcal{O}_V(U)$.
Now let $f\in\mathcal{O}_V(U)$, by definition we have for any $p$ in $U$, we can choose a neighborhood $U_p$ of $p$ such that $$ \left.f\right|_{U_p}=\frac{h_p}{k_p} $$ for some polynomial $h_p$ and $k_p$ and $k_p(p)\neq 0$.
Because Zariski topology is compact, we can select finitely many such neighborhood, indexed by $i=1,\cdots,n$.
Because $k_i$c cannot simultaneously vanish on $U$, we must have $$ \mathbb{V}(k_1,\cdots,k_n)\subset U^C=\{(0,0)\} $$
If $\mathbb{V}(k_1,\cdots,k_n)=\varnothing$, then $(k_1,\cdots,k_n)=(1)$, then we can select $$ 1=\sum_{j}l_jk_j $$ for some $l_j$, and the rest is easy.
My problems lies in the case $\mathbb{V}(k_1,\cdots,k_n)=\{(0,0)\}$ which follows $$ (k_1,\cdots,k_n)=(x,y) $$ and I don't know how to move on...