I wrote my undergraduate thesis on a very concrete application of the fractional calculus to Lagrangian Mechanics. For those of you who aren't physicists, Lagrangian Mechanics is a reformulation of classical mechanics that is valid for all coordinates $(q,\dot{q},t)$. Lagrangian Mechanics gives us the same results of Newton's Laws while being much more flexible. It is also the starting point for both quantum mechanics and general relativity.
This is how it works. Let $L(q,\dot{q}) = T - V$ where $T$ and $V$ respectively denote the kinetic and potential energy of the system.
Given a functional of the form
$$
S[L(q,\dot{q},t)] = \int_a^b L(q,\dot{q})dt
$$
and applying the calculus of variations, we arrive at the Euler-Lagrange equation
$$
\frac{\partial L}{\partial q} - \frac{d}{dt}\Big(\frac{\partial L}{\partial \dot{q}}\Big) = 0
$$
which you can then integrate to find the equations of motion of the system. There is a problem, however, and that is that you cannot extremize the action if $L$ has a term in it that is explicitly time-dependent. So? Historically this has meant that Lagrangian mechanics--and by extension quantum mechanics--has only been done for a very special kind of interactions, those we call conservative.
The good news is that using fractional derivatives, it is possible to rederive a version of the Euler-Lagrange equation that is valid for nonconservative systems, e.g. anything involving dissipation. It looks like this:
$$
\frac{\partial L}{\partial q} + {_bD_t^{\alpha}}\Big[\frac{\partial L} {\partial {_bq_t^{\alpha}}} \Big] + {_bD_t^1}\Big[\frac{\partial L}{\partial {_bq_t^1}}\Big] = 0
$$
The physical implication is that fractional mechanics give us a notion of path memory for dynamical systems.