Let $n \geq 2$ be an integer, $p$ a prime with $p^e$ the highest power of $p$ dividing $n$. Then $\binom{n}{p^e}$ is not divisible by $p$.
I think you can do it using this formula for $\binom{n}{k}$. From that post we have that
$$ \binom{n}{r} = (\prod_{n-r\lt p\leq n} p^{k_p(n)})(\prod_{r\lt p\leq n-r} p^{k_p(n) - k_p(n-r)})(\prod_{p\leq r}p^{k_p(n)-k_p(n-r)-k_p(r)}) $$
Well $p$ falls into the class $p \leq r= p^e$. So it suffices to show that $k_p(n) - k_p(n-p^e) - k_p(p^e) = 0$ where $k_p(n) = \sum_{k\geq 1} \lfloor \frac{n}{p^k}\rfloor$. Well, $k_p(n) = k_p(mp^e) = m + mp + mp^2 + ... mp^{e-1}$, and
$$ k_p(n - p^e) = k_p((m - 1)p^e) $$
but $m-1$ could equal $\ell p^k$ for some $k$. So I'm not sure where to go from here. Alternative simpler proofs welcome.
The proof from the book goes like this: For each $n-k$ divisible by $p$ in the numerator of $\binom{n}{p^e}$, $n-k = mp^e - \ell p^i$. It says "then $i \lt e$", but I don't how that's true. Without that requirement we have either $e = i, \ e \gt i,$ or $e \lt i$. Let's see. If $e \leq i$, then $p^e - k = p^e(1 - \ell p^{i-e})$, but there is not such $p^e-k$ in the denominator so $e \gt i$. It then says $(m-k) = (p^e - k)$ and $(n-k) = (p^em - k)$ are both divisible by $p^i$ but not $p^{i+1}$. How did they get $m-k = p^e - k$?