Let $\mathsf{ZFC_2}$ denote $\mathsf{ZFC}$ with a second-order replacement axiom. It has been discussed in some other answers that every model of $\mathsf{ZFC_2}$ is isomorphic to $V_\kappa$ for some inaccessible cardinal $\kappa$. But it seems to me that the intended "model" of $\mathsf{ZFC}$ is supposed to be the proper class $V$, so it seems natural to ask whether $V$ is unique as a "class model" of $\mathsf{ZFC_2}$ in some sense.
Let's define "class model" to be a model whose underlying "set" is a proper class. And let's define "class categorical" to mean that all class models are isomorphic. Then is $\mathsf{ZFC_2}$ class categorical?
The intuition behind this idea is an analogy with $\mathsf{PA}$. First-order $\mathsf{PA}$ has many distinct non-standard models. But $\mathsf{PA_2}$ is categorical and singles out the informally "intended" model uniquely (up to isomorphism). So the thought is, maybe $\mathsf{ZFC_2}$ does the same for the "intended model" of $\mathsf{ZFC}$. That said, I have no idea what sorts of thorny issues might arise when we try extending models and categoricity to encompass proper classes.