$2^4=16=4^2$. In fact, $\{2,4\}$ is the only pair of natural numbers with that property, i.e. if $m<n$ are natural numbers and $m^n=n^m$, then $m=2$ and $n=4$.
This is easily seen with some analysis: For $m,n\in\mathbf{N}\backslash\{0\}$, the equation $m^n=n^m$ is equivalent to $\sqrt[m]{m}=\sqrt[n]{n}$. By calculus, we can show that the real function $t\mapsto \sqrt[t]{t}$ is strictly increasing for $t<e$ and strictly decreasing for $t>e$. So the smaller of the two numbers has to be $<e$ and the proposition follows.
My question: Is there an elementary proof? By elementary I mean most of all no irrational numbers, no calculus.