$$\sum_{k=0}^n \frac{(2n)!}{(k! (n-k)!)^2} = \binom{2n}{n}^2$$
The original combinatorial interpretation was something like how many strings of length $2n$ with 4 letters A,B,C,D have $k$ A's, $k$ B's, $n-k$ C's, and $n-k$ D's. From looking at the first few values, this looks like the square of the number of strings of length $2n$ with 2 letters, $n$ A's and $n$ B's.
Is there a nice combinatorial proof for this? I was thinking something like taking two strings with $n$ A's and $n$ B's, for example AAABBB and ABABAB, then mapping each pair of letters from both strings to one of four new letters. Then there are $k$ AA's, $n-k$ AB's, $k$ BB's, and $n-k$ BA's. Is this correct? Is there a nice algebraic proof too?