The Wikipedia page on the inscribed square problem mentions that an analog of the problem involving triangles instead of squares does hold. However, it doesn't mention anything about triangles inscribed in arbitrary, possibly non-simple, closed plane curves, and I couldn't find any results online for arbitrary closed plane curves either. Naturally, the result is trivial for all closed plane curves that admit some Jordan subcurve, so I started wondering whether all closed plane curves admit Jordan subcurves, but I had no luck finding a proof or a counterexample.
So, I originally posed five questions. The first question was whether nonconstant closed plane curves always admit nonconstant Jordan subcurves, and the second was an analog of the question for general $\mathbb{R}^{n}$. MoisheKohan pointed out in the comments that a closed plane curve whose image is an interval is a counterexample to both. As such, I am now posing a separate but related question in addition to the three other unresolved questions below (still ordered in ascending generality.)
Modified question on closed Euclidean curves: what are some nontrivial necessary or sufficient conditions on nonconstant closed Euclidean curves $\gamma : [0,1] \rightarrow \mathbb{R}^{n}$ with $\gamma(0) = \gamma(1)$ to guarantee the existence of a nonconstant simple closed subcurve $\gamma_{s} : [0, 1] \rightarrow \mathbb{R}^{n}$ with $Im(\gamma_{s}) \subseteq Im(\gamma)$ and $\gamma_{s}(0) = \gamma_{s}(1)$? (e.g. if the set of points where $\gamma$ is injective has a subset of points that is dense-in-itself, then is that sufficient?)
For open Euclidean curves on closed intervals: let $\gamma : [0, 1] \rightarrow \mathbb{R}^{n}$ be an arbitrary Euclidean path satisfying $\gamma(0) \neq \gamma(1)$. Does there exist a nonconstant simple subcurve $\gamma_{s} : [0, 1] \rightarrow \mathbb{R}^{n}$ such that $Im(\gamma_{s}) \subseteq Im(\gamma)$ and $\gamma_{s}(0) = \gamma(0), \gamma_{s}(1) = \gamma(1)$?
For general Euclidean curves: let $I \subseteq \mathbb{R}$ be an arbitrary interval, and $\gamma : I \rightarrow \mathbb{R}^{n}$ be an arbitrary Euclidean curve. If $\gamma$ is nonconstant, then does there exist an interval $I_{s} \subseteq \mathbb{R}$ and a nonconstant simple subcurve $\gamma_{s} : I_{s} \rightarrow \mathbb{R}^{n}$ such that $Im(\gamma_{s}) \subseteq Im(\gamma)$?
For general curves: same statement as the general Euclidean curve question, just with an arbitrary topological space $X$ replacing $\mathbb{R}^{n}$.