I write in Polish notation and have included fully infixed notation here also which indicates parsing order.
For every relevant logic simplification fails:
Simplifcation: $CpCqp$ or $\big(p\rightarrow(q\rightarrow p)\big)$
I have a proof that from Syllogism, Commutation, Conjunction-Out Left, and Conjunction-in I can deduce $CpCqp$, given detachment also. You may see the August 19th answer here for details.
Syllogism: $CCpqCCqrCpr$ or $\Big((p\rightarrow q)\rightarrow\big((q\rightarrow r)\rightarrow(p\rightarrow r)\big)\Big)$
Commutation: $CCpCqrCqCpr$ or $\Big(\big(p\rightarrow(q\rightarrow r)\big)\rightarrow\big(q\rightarrow(p\rightarrow r)\big)\Big)$
Conjunction-Out Left: $CKpqp$ or $\big((p\land q)\rightarrow p\big)$
Conjunction-In: $CpCqKpq$ or $\Big(p\rightarrow\big(q\rightarrow(p\land q)\big)\Big)$
I highly doubt relevant logics don't have $CCpqCCqrCpr$ or $CKpqp$ when the have a conjunction connective. Does $CpCqKpq$ not hold for some relevant logics, and $CCpCqrCqCpr$ not hold for others? Or do they both fail for all relevant logics? Or does only one of them not hold? If so, which one?