Why is $x^6-x^5 + x^3 - x^2 + 1$ irreducible over $\mathbb{Z}[x]$?
It clearly has no integer roots, and in fact no real roots. Every polynomial with real coefficients can be written as a product of quadratic and linear terms. But I'm not sure how to factor the above polynomial. Maybe some sort of theorem involving irreducible integer polynomials might be useful?