Usually, whether a statement $P(x)$ about a free variable $x$ is true or false depends on the value or meaning of $x.$
For example, if $P(x)$ means $x\in \{ 1, -9, 15 \},$ we can neither say that $P(x)$ is true nor that it is false if we don't know what $x$ is.
But can we say that the statement $$x\in\emptyset$$ is false? After all, it does not have any quantifier.
On the other hand, these five examples all have quantifiers (either $\forall x$ or $\exists x$), and
$\forall x(x\in \emptyset \Rightarrow P(x))$ is vacuously true.
$\forall x(x \in U \Rightarrow x \in \emptyset)$ is false.
$\exists x(x \in U \land x\in \emptyset)$ is false.
$\exists x(x \in \emptyset)$ is false.
$\forall x(x \in \emptyset)$ is false.