When the numbers in question are algebraic, the theory of algebraic field extensions and Galois theory (etc) can come in handy. I'm going to assume familiarity with abstract algebra in my response, but if there are any details you'd like me to expound on let me know and I can.
To give a concrete example, one can show that the set $\{\sqrt{n}:\text{$n$ is a squarefree integer}\}$ is linearly independent over $\mathbb Q$ (which greatly generalizes your six square root example). To see this, we need to establish some tools:
If $K\supseteq F$ is a Galois field extension of finite degree, then let $\text{Aut}_F(K)$ denote the group of field automorphisms of $K$ fixing $F$. Given such an automorphism group (call it $G$ for brevity), we can define the corresponding trace via $T(\alpha)=\tfrac{1}{|G|}\sum_{g\in G} g(\alpha)$, i.e. the average of the orbit of $\alpha$ with respect to $G$. One can easily verify that the trace is a linear operator and fixes elements of the base field $F$.
Claim: If $\alpha$ is a square root of a rational number that is not itself rational and $K\supseteq \mathbb Q$ is a Galois field extension of finite degree with $\alpha\in K$, then the corresponding trace satisfies $T(\alpha)=0$.
Sketch of proof: The minimal polynomial of $\alpha$ is $x^2-\alpha^2$, which in particular has $\pm \alpha$ as roots. Since the extension is Galois, elements of the automorphism group send $\alpha$ to each of $\pm \alpha$ equally often, for an overall sum of $0$.
With this in hand, we're ready to prove that the set $S=\{\sqrt{n}:\text{$n$ is a squarefree integer}\}$ is linearly independent over $\mathbb Q$. To do this, suppose we have a finite linear combination $0=\sum_{i=1}^n c_i \sqrt{b_i}$ where each $c_i\in \mathbb Q$ and each $\sqrt{b_i}\in S$ (and hence each $b_i\in \mathbb Q$). Multiplying everything by $\sqrt{b_1}$ gives $0=c_1b_1+\sum_{i=2}^n c_i\sqrt{b_ib_1}$. One can easily check each of these latter terms remains irrational, so taking the corresponding trace gives $0=c_1b_1$, so since $b_1\neq 0$, we know $c_1=0$. Applying the same argument yields that all of the $c_i$ are $0$, as desired.
When the numbers in question are transcendental... good luck (e.g. it's unknown whether or not $e+\pi$ is rational).