For example:
$$\int a^x \, dx = \int e^{x \ln a } \, dx$$ Let $u= (\ln a) x$
From here: $$ \frac{du}{dx} = \ln a $$ $$ \frac{1}{\ln a} du= dx $$
$$\int e^{x \ln a } \, dx = \int e^u \, du = \frac{1}{\ln a} e^u + C = \frac{1}{\ln a} a^x + C $$
This uses du/dx as a fraction, how can you change the base of an integral without doing this?
In the question Is $\frac{\textrm{d}y}{\textrm{d}x}$ not a ratio? many people say $dy/dx$ is not a fraction.