There's the $n$ such that $6n \pm 1$ is a twin prime pair sequence: https://oeis.org/A002822 It contains all twin prime averages (divided by $6$) other than $4$.
Notice this sequence: Positive numbers $n = 6xy + x + y$ such that $x,y \in \Bbb{Z}$. That sequence is the complement (all entries found in $\Bbb{N}$ that are not in A002822, by its very definition).
But notice the $6xy + x + y$ part. That reminded me of the Sieve of Sundaram's $2ij + i + j$ form. Thus:
Start with a list of integers from $81$ to $N$, and cross out all elements of the form $6ij + ki + lj$ such that $k, l \in \{1,3,5\}$ and $i,j \geq 1$. Then taking the remaining elements, multiplying them by $6$ and adding respectively $lk = 1,3,5,9,15, $ or $25$; and of course we union the result of each case / cross-out form.
We have the following possibilities:
$$ 6(6ij + i + j) + 1 = (6i + 1)(6j + 1) \\ 6(6i + i + 3j) + 3 = (6i + 3)(6j + 1) \\ 6(6ij + i + 5j) + 5 = (6i + 5)(6j + 1) \\ 6(6ij + 3i +3j) + 9 = (6i + 3)(6j + 3) \\ 6(6ij + 3i + 5j) + 15 = (6i+5)(6j+3) \\ 6(6ij + 5i +5j) + 25 = (6i + 5)(6j + 5) \\ $$
The above will cover all odd numbers $\geq 81$ which we find by setting $i=j = 1$ and computing the smallest formula above which is $(6i + 1)(6j + 1) = 81$.
Thus we've filtered out all and only composites $\geq 81$, clearly, and via inspection of the above factorizations.
See: Sieve of Sundaram.
However, all primes $\gt 3$ are of the form $6n + 1$ or $6n + 5$. Thus we can cross out lines $2,3,5$ in the above 6 formulas, or namely the lines with added $3,9,15$. But $6n + 25 = 1 \pmod 6$ so it is left and the list of cross-out forms in the generalized Sundaram sieve becomes:
$$ 6ij + i + j \\ 6ij + i + 5j \\ 6ij + 5i + 5j \\ i,j \geq 1 $$
Thus, that is the Sundaram sieve method genralized to a multiple of $6$ instead of just $2$. You could probably do similarly, with other multiples.
Question. Can we remove even more unecessary cross-out forms so that there would be less than $3$?