If $Q$ is positive semidefinite, then $AQ^{-1}A^T$ will always be positive semidefinite.
If $Q$ is positive definite, then it can be written in the form
$$
Q = H + K,
$$
where $H = \frac 12(Q + Q^T)$ is symmetric and positive definite and $K = \frac 12(Q - Q^T)$ is skew-symmetric. Because $H$ is positive definite, there exists an invertible matrix $P$ such that $S = PP^T$, and we have
$$
P^{-1}QP^{-T} = P^{-1}HP^{-T} + P^{-1}KP^{-T} = I + P^{-1}KP^{-T}
$$
where $I$ denotes the identity matrix. Note in particular that $J:= P^{-1}KP^{-T}$ is a skew-symmetric matrix. Note that $Q^{-1}$ is positive definite if and only if the matrix
$$
P^TQ^{-1}P = [P^{-1}QP^{-T}]^{-1} = [I + J]^{-1}
$$
is positive definite. Thus, we have reduced the question to that of whether/when $[I + J]^{-1}$ is positive definite for a skew-symmetric $J$.
Note that a matrix $M$ is positive definite if and only if the symmetric matrix $M + M^T$ is positive semidefinite. Taking $M = [I + J]^{-1}$, we have
$$
M + M^T = [I + J]^{-1} + [I + J]^{-T} = [I + J]^{-1} + [I - J]^{-1}.
$$
I claim that this can be rewritten as
$$
[I + J]^{-1} + [I - J]^{-1} = 2[(I + J)(I - J)]^{-1} = 2 (I - J^2)^{-1}.
$$
Now, we note that $I - J^2$ is necessarily positive definite because it is the sum of a positive definite matrix $I$ and a positive semidefinite matrix $-J^2 = JJ^T$. Thus, $(I - J^2)^{-1}$ and hence $(I + J)^{-1}$ is positive definite.