My proof:
By the way of contradiction, suppose that we found $(x,y) \in \mathbb N^*$ satisfies:$$\frac{x+y}{xy}=5$$ So : $$x+y=5xy \\ \iff x=5xy-y \iff x=y(5x-1)$$ Since $x\in \mathbb N^* $ so the minimum value of $5x$ is $5>1 \implies y\mid x$
By the same method we have: $$y=x(5y-1) \implies x\mid y$$ $x\mid y, y\mid x \implies x=y$, Now we can write the original equation as : $$\frac{2x}{x^2}=5 \iff 2=5x \implies x\notin \mathbb N^* $$ Therefore there is no solution to this equation: $$\frac{x+y}{xy} =5$$
Does this considered a proof?