Concerning Question 1:
Let $n=3^rps$, where $p$ is a prime, $p\ge5$, and $s$ is not a multiple of $3$. Let $m=3^rt$ where $ps>t>0$ and $ps+t$ is a multiple of $3$. Let $\zeta=e^{2\pi i/3^{r+1}}$. Then $\zeta^n+\zeta^m+1$ is the sum of the three cube roots of unity, so it's zero, so $x^n+x^m+1$ is divisible by the minimal polynomial for $\zeta$. That polynomial has degree $2\times3^r$, which is less than $n$, so $x^n+x^m+1$ is reducible.
Now let $n=4t$ for some $t$. Then $$x^n+x^{n/2}+1=x^{4t}+x^{2t}+1=(x^{2t}+x^t+1)(x^{2t}-x^t+1)$$ so $x^n+x^{n/2}+1$ is reducible.
This only leaves $n$ of the form $3^r$ and $2\times3^r$ to consider. Suppose $n$ is of one of these forms, and consider $x^n+x^m+1$, $0<m<n$. At this point, we have to bring in the big result of the papers cited at mathoverflow.net/questions/56579/about-irreducible-trinomials. This says that $x^n+x^m+1$ has at most one non-cyclotomic factor, where by cyclotomic factor I mean a polynomial whose zeros are all at roots of unity. That is, $x^n+x^m+1$ is either $P(x)$ or $Q(x)$ or $P(x)Q(x)$, where $P(x)$ is a cyclotomic factor, and $Q(x)$ is an irreducible non-cyclotomic factor. If it's $Q(x)$, then we're done – we've proved it's irreducible, as requested. So, we assume it has a cyclotomic factor $P(x)$, which has a root $\zeta$, which is a root of unity. Then $\zeta^n+\zeta^m+1=0$, a vanishing sum of three roots of unity, which can only be the sum of the three cube roots of unity. From this, I want to conclude that we must have $n=2\times3^r$, $m=3^r$, and $x^n+x^m+1$ is the minimal polynomial for $\zeta$, hence, irreducible, and we're done, but I'm not seeing it right now. I'll try to come back to finish this up in a day or two.