Let $R$ be an integral domain with fraction field $K$, and let $\mathcal{T}$ be the set of subrings $T$ of $K$ such that $R\subseteq T$.
Call $R\;$unit-complete$\;$if for all $T\in \mathcal{T}$, either $T=R$ or $T$ has a unit element which is not in $R$.
Call $R\;$strongly unit-complete$\;$if for all $T\in \mathcal{T}$, either $T=R$ or $T$ contains ${\large{\frac{1}{r}}}$ for some non-unit element $r\in R$.
It's immediate that strongly unit-complete implies unit-complete.
It's easily shown that if $R$ is a $\text{PID}$, then $R$ is strongly unit-complete.
Proof:
Let $R$ be a PID with fraction field $K$, and let $T$ be a subring of $K$ with $R\subset T$ (proper inclusion).
Fix $t\in T{\setminus}R$, and write $t={\large{\frac{a}{b}}}$, where $a,b\in R$ are such that $b$ is a non-unit of $R$ and $\gcd(a,b)=1$.
From ${\large{\frac{a}{b}}}\in T$, we get $1-{\large{\frac{a}{b}}}\in T$, so ${\large{\frac{b-a}{b}}}\in T$.
From $\gcd(a,b)=1$, we get $\gcd(a,b-a)=1$.
Then since $R$ is a $\text{PID}$, there exist $u,v\in R$ such that $ua+v(b-a)=1$, so $$ \frac{a}{b},\frac{b-a}{b}\in T \implies u\Bigl(\frac{a}{b}\Bigr)+v\Bigl(\frac{b-a}{b}\Bigr)\in T \implies \frac{1}{b}\in T $$ hence $R$ is strongly unit-complete.
Some questions:
$(1)\;$If a noetherian integral domain $R$ is strongly unit-complete, must $R$ be a $\text{UFD}$?
$(2)\;$Is there an integral domain $R$ which is unit-complete but not strongly unit-complete?