This is a vague and broad question so I'll interpret it vaguely and broadly. Here are some nice facts about polynomials $f(x) \in \mathbb{Z}[x]$ that aren't true of more general polynomials, that can be used to prove some stuff:
Fact 1: $a - b \mid f(a) - f(b)$.
For example, $f(1) \equiv f(3) \bmod 2$ and so forth. This is an easy observation but it's a strong and useful constraint on the values that an integer polynomial can take, and in particular it shows that unlike over a field, we can't make an integer polynomial take arbitrary integer values at a finite set of points. It can be used to give a Euclid-style proof of the fact that the set of prime divisors of the values of $f$ must be infinite, which in turn can be used to prove, for example, that the set of primes congruent to $1 \bmod 4$ is infinite, by taking $f(x) = x^2 + 1$.
Fact 2: If $f(x)$ is monic and has nonzero constant term then it has at least one complex root of absolute value at least $1$. Hence if you can show that $f(x)$ has exactly one such root then it must be irreducible.
This can be used to prove Perron's criterion, and a variant of this argument was used on MathOverflow (due to Bjorn Poonen going off of an observation I made) to prove that the polynomials $x^n + p_1 x^{n-1} + \dots p_{n-1}$ are always irreducible, where $p_i$ are the primes! A similar argument also proves this irreducibility criterion which is sort of a mix of the previous two and which doesn't have a name that I know of.
Fact 3: If $f(x)$ is monic and has constant term $\pm 1$ then either it has at least one complex root of absolute value greater than $1$ and another of absolute value less than $1$, or all of its roots have absolute value exactly $1$.
In the latter case it turns out that all of the roots must in fact be roots of unity (so $f$ must be a product of copies of $x$ and the cyclotomic polynomials); this is due to Kronecker and you can find the proof here, which crucially relies on the observation that there are finitely many integer polynomials of a given degree with a given bound on the size of the coefficients. I use this same observation here to show that there exists a nontrivial lower bound on the absolute value of the largest root (in absolute value) of a monic polynomial $f(x) \in \mathbb{Z}[x]$ with constant term $\pm 1$.
In general using the discreteness of the integers is a very common proof technique and there are many examples although it's hard to search for them at that level of generality.