Assume $m=-n > 0$.
If $m$ isn’t a fourth power, and $X^4+n$ is reducible, it means that there is a quadratic algebraic integer $\alpha$ with $\alpha^4=m$.
$\alpha$ is a quadratic algebraic integer so it can be written as $a+b\sqrt{D}$ for integers $a,b$ and square-free $D \neq 1$, or $\frac{a+b\sqrt{D}}{2}$ with furthermore $4|D-1$ and $2|a-b$.
Then $\alpha^2$ is real, so if $D < 0$, $\alpha$ is pure imaginary and $\alpha^2$ must be a real element of an imaginary quadratic field over $\mathbb{Q}$, so is rational, and $m$ is a perfect square – we are in the case $X^4-p^2$.
If $D > 0$, then $\alpha$ is real so $\alpha=\pm m^{1/4}$, so, $\alpha^2$ is $\sqrt{m}$ and is a rational linear combination of $1$ and $\sqrt{D}$, which implies $m=c^2D$ for some integer $c$.
Thus $\alpha=\pm \sqrt{c\sqrt{D}}$ is a quadratic integer over $\mathbb{Q}$. But $\alpha=a+b\sqrt{D}$ where $2a,2b$ are integers. Taking squares, we find $a^2+b^2D=0, 2ab=c$, which implies (as $D$ is square free) a contradiction.
So if $n < 0$, $X^4+n$ is reducible iff $-n$ is a perfect square ($X^4-m^2=(X^2-m)(X^2+m)$).
Assume $n > 0$ and $X^4+n$ reducible. Then there is a quadratic algebraic integer $\alpha$ such that $\alpha^4=-n$, ie $\alpha^2=\pm i\sqrt{n}$.
Let $d$ be the product of prime factors with odd valuation of $n$, (so that $\sqrt{n} \in \mathbb{N}\sqrt{d}$) it follows that $\alpha=a+ib\sqrt{d}$ where $2a,2b$ are integers. As $\alpha^2 \in i\mathbb{N}\sqrt{d}$, it follows $a^2=db^2$, which forces $d=1$ ie $n$ is a square.
As $n=c^2$, $c>0$, then $\alpha^2=\pm ic$, so that $\alpha=(\pm 1 \pm i)(c/2)^{1/2}$.
So (with complex conjugation), the question is as follows: when is $u=(1+i)\sqrt{c/2}$ a quadratic integer?
Assume $u$ quadratic integer. Then $K=\mathbb{Q}(u)$ is stable under conjugation and $\overline{u} \in K$. But $\frac{u}{\overline{u}}=(1+i)(1-i)^{-1}=(1+i)^2/2=i$, so $i \in K$ and $K=\mathbb{Q}(i)$. Thus the real part of $u$ is rational, ie $c/2$ is a square.
Finally, it follows that the only cases where $X^4+n$ is reducible are the “trivial ones”:
if $-n$ is a square (difference of squares)
if $n=4a^4$ (Sophie Germain)