For every topological space $M$ and some $k \geq 2$, recall the fat diagonal $M^k_{k-1} \subset M^k$, defined via
$$ M^k_{k-1} := \{(x_1,\dots,x_k) \in M^k : \exists i \neq j \text{ with } x_i = x_j\}.$$
I would like to understand the relative homology $H_\bullet(M^k, M^k_{k-1})$ for $M = S^1$ and $k$ arbitrary. Since this seems like a good pair to me, we can identify $$H_\bullet(M^k, M^k_{k-1}) \cong \tilde{H}_\bullet(M^k / M^k_{k-1}),$$
but now I've already run out of quick and dirty ideas. Any hints or suggestions? And is there something even more general one can say outside of the case $M = S^1$?