Let $p,q$ be distinct primes. Prove that the six integers $pq-2$, $pq+2$, $pq-4$, $pq+4$,$pq-6$, $pq+6$ cannot be all primes.
This is Exercise 5.60 in Chartrand's Mathematical Proofs. The claim is intriguing as for $p=3$ and $q=5$, the four integers $pq-2$, $pq+2$, $pq-4$, $pq+4$ are all primes. I haven't been able to explain why it stops working when $pq-6$ and $pq+6$ are added in the hypothesis.
I think I should look for a proof by contradiction. I don't know where to use the assumption that $p$ and $q$ are distinct primes.
I wonder if there is something peculiar about the prime gaps in this problem. I don't have any other clue.