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Let $n \geq 1$. Is there a closed form, or an asymptotic estimate, for the number $g(n)$ of families $\mathcal{F} \subseteq 2^{[n]}$ which are closed under union and intersection?

An obvious upper bound is $2^{2^n}$. We can furnish a lower bound by considering chains $\varnothing=S_0 \subsetneq S_1 \subsetneq S_2 \cdots \subsetneq S_m=[n]$, and the combinatorics of counting such chains do not seem too daunting, and can be solved using the Partition function.

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According to A306445, the formula is given by $$g(n)=1+\sum_{d=0}^{n}\sum_{i=d}^{n} {n \choose i}{i \choose i - d}f(d)$$

where $f(d)$ is the number of topologies on a finite set of $d$ elements. Per this, we have the estimate $\log_2 f(d) \sim d^2/4$.