It is quite correct and sometimes useful to say that, for example, $\dbinom 4 6=0,$ i.e. the number of subsets of size $6$ of a set of size $4$ is $0.$ So what you write is correct.
For example, suppose a subcommittee of $6$ members is to be chosen from a committee of $4$ Republicans and $10$ Democrats. The number of such subcommittees is $\dbinom{14}6.$ The number of Democrats on the subcommittee belongs to the set $\{0,1,2,3,4,5,6\},$ and so does the number of Republicans, but that number cannot be $5$ or $6.$ Now suppose we want the probability that the Democrats are a majority of the subcommittee. The number of ways to get $4$ Democrats and $2$ Republicans is $\dbinom {10} 4\cdot \dbinom 4 2.$ The number of ways to get $5$ Democrats and $1$ Republicans is $\dbinom {10} 5\cdot \dbinom 4 1.$ And the number of ways to get $6$ Democrats and $0$ Republicans is $\dbinom {10} 6\cdot \dbinom 4 0.$ (And this last is an example of why the concept of the empty set makes sense: if the number of ways to get $0$ Republicans is not $1$ the we get a wrong answer here.) In the same way, the number of ways to get $5$ Republicans and $1$ Democrat is $\dbinom {10} 1\cdot\dbinom 4 5 = 0.$ And that shows up here:
$$
\binom {14} 6 = \sum_{k=0}^6 \binom 4 k \cdot \binom {10} {6-k} \tag 1
$$
If we don't allow things like $\dbinom 4 5 =0,$ then identities like $(1)$ could not be presented without complicating things by talking about exceptions or about the narrow enough class of cases to which identities like this apply.
What you wrote is correct, but in some contexts, just as one writes $\dbinom 8 3 = \dfrac{8\times7\times6}{3\times2\times1},$ so one also writes $\dbinom {8.4} 3 = \dfrac{8.4\times7.4\times6.4}{3\times2\times1}.$ For example, this comes up in the binomial expansion:
$$
(1+x)^{8.4} = 1 + 8.4x + \binom{8.4}2 x^2 + \binom {8.4}3 x^3 + \cdots \text{ for } |x|<1.
$$
And negative integers in this context have a combinatorial interpretation:
$$
\left| \binom{-8} 3 \right|
$$
is the number of submultisets of size $3$ in a set of size $8.$