It would seem that a preceding query would be on point, but not really for me. One of the answers comes close, but it isn't complete as is. Since the answer is going to be an integer, all the factors in the denominator will cancel. Prime factors can be eliminated by any factor in the numerator that is a multiple. The problem is composites; canceling them out may involve multiple numerator factors that share primes. And there's the auxiliary problem of determining prime factors from composite ones (i.e. which composite factor(s) in the numerator should I cancel a composite factor in the denominator against).
I'm thinking of an analogy with computing the greatest common divisor of two positive integers. You could determine GCD by breaking both arguments into their prime factorizations, then use the minimum exponent for each prime. But using something like Euclid's algorithm is a lot easier. For a multinomial coefficient, I could run a Sieve of Eratosthenes up to the numerator's maximum factor, use that table to get all the applicable prime factorizations, then do a bunch of cancelling, but that seems like a lot of work. Is there a procedure similar to Euclid's GCD one that we can make for binomial coefficients?