We use the coefficient of operator $[z^i]$ to denote the coefficient of $z^i$ of a series. This way we can write for instance
\begin{align*}
[z^i](1+z)^n=\binom{n}{i}\tag{1}
\end{align*}
We obtain
\begin{align*}
\color{blue}{\sum_{i=0}^{\left\lfloor \frac{n}{2}\right\rfloor}}&\color{blue}{\binom{n}{i}\binom{n-i}{i}}\tag{2}\\
&=\sum_{i=0}^{n}\binom{n}{i}[z^i](1+z)^{n-i}\tag{3}\\
&=[z^0](1+z)^n\sum_{i=0}^{n}\binom{n}{i}\left(\frac{1}{z(1+z)}\right)^i\tag{4}\\
&=[z^0](1+z)^n\left(1+\frac{1}{z(1+z)}\right)^{n}\tag{5}\\
&\,\,\color{blue}{=[z^{n}](1+z+z^2)^n}\tag{6}
\end{align*}
Comment:
In (3) we apply the coefficient of operator according to (1). We also set the upper limit to $n$ without changing anything, since $\binom{n-i}{i}=0$ if $i>\left\lfloor\frac{n}{2}\right\rfloor$.
In (4) we use the rule $[z^{p-q}]A(z)=[z^p]z^qA(z)$.
In (5) we apply the binomial theorem.
In (6) we do some simplifications and use again the rule as in (3).
We observe the binomial sum (2) represents essentially central trinomial coefficients
\begin{align*}
[z^n](1+z+z^2)^n
\end{align*}
for which there is no closed form available.
Notes from the experts:
D.E. Knuth gives in Concrete Mathematics, Appendix A 7.56 the following representation of a more general expression
\begin{align*}
[z^n](a+bz+cz^2)^n=[z^n]\frac{1}{\sqrt{1-2bz+(b^2-4ac)z^2}}
\end{align*}
He states that according to the paper Hypergeometric Solutions of Linear Recurrences with Polynomial Coeffcients by Marko Petkovšek there exists a closed form (more precisely: a closed form solution as a finite sum of hypergeometric terms) if and only if
$$\color{blue}{abc(b^2-4ac)=0}$$
In case of central trinomial coefficients we have $a=b=c=1$. Since then the expression $abc(b^2-4ac)=-3\ne 0$
there is no such closed form in particular for the central trinomial coefficients.