I would have used the fundamental group as @Hayden, but you want a differential argument, so here it goes.
Since the tangent bundles $T\mathbb{S}^1$, $T\mathbb{S}^3$ are trivial (you can check this in Spivak's Volume 1, e.g, but the fact that $T\mathbb{S}^1$ is trivial is clear from the looks, and $\mathbb{S}^3$ is a Lie group, so it's parallelizable), then $T(\mathbb{S}^1\times\mathbb{S}^3)\cong T\mathbb{S}^1\times T\mathbb{S}^3$ is again trivial.
This is not the case for $\mathbb{S}^2\times\mathbb{S}^2$.
To see this, observe that since $\mathbb{S}^2\times\mathbb{S}^2$ is a $CW$-complex, we can use any of its $CW$ structures to compute its Euler characteristic. For example, use the one for $\mathbb{S}^2$ with one $0$-cell and one $2$-cell, to get one in $\mathbb{S}^2\times\mathbb{S}^2$ with one $0$-cell, two $2$-cells and one $4$-cell. Then its Euler characteristic is 4, now use the Poincaré-Hopf Index Theorem to prove that any vector field on $\mathbb{S}^2\times\mathbb{S}^2$ must have a zero, contradicting a possible triviallity of its tangent bundle.
$\textbf{Credit}:$ to Mike Miller for the final argument using the Euler characteristic.