$x^{2^n} + 1$ is irreducible in $\mathbb Q[x]$.
I've been working on this and this is my process: I would like to use Eisenstein's criterion so I considered the substitution $y=x-1$. So $$x^{2^n}+1=(y+1)^{2^n}+1=\sum_{k=0}^{2^n}{2^n \choose k}y^{2^n-k}+1$$ $$={2^n \choose 0}y^{2^n}+{2^n \choose 1}y^{2^n-1}+\ldots+{2^n \choose 2^{n}-1}y+2$$ Take $p=2$. Since $p$ doesn't divide $1=a_{2^n}$ and $p^2=4$ doesn't divide $2=a_0$ it only remains to show that every ${2^n \choose j}$ for $1\leq j \leq 2^n-1$ is divisible by $2$ but I haven't succed showing the latter. Any ideas? Also, is my process correct? Thanks in advance