One of the things that you want in Dedeking rings is that you have nice ideal factorisation properties. In particular, multiplication by a nonzero ideal should be injective.
Suppose $R$ is a commutative ring. Let us look at an element $x/y$ of its field of fractions who happens to be a solution of a monic polynomial equation :
Let $x,y \in R$ and $a_k \in R$ for $k=0 \ldots n-1$ and suppose the equation
$x^n = \sum a_k x^k y^{n-k}$ is true.
Now consider $I = (x,y)$, the ideal generated by $x$ and $y$. Then,
$I^n = (x^n,x^{n-1}y, \ldots, xy^{n-1},y^n)$. But, because of that equation, the first generator is superfluous, and so $I^n = (x^{n-1}y,\ldots, xy^{n-1},y^n)$.
If you look at this ideal carefully, you get $I^n = (y)I^{n-1}$.
Now, if you want your ideals to have nice factorization properties, and if $I$ is nonzero you would want $(y) = I$. Since $I = (x,y)$, this is equivalent to $x \in (y)$, so that there exists a $z \in R$ such that $x=yz$, or also that $x/y \in R$.
Therefore if you want nice ideal factorisations, you need $R$ to be integrally closed.
(checking that a few ideals factor as they should is also what I do when I want to check if a ring is integrally closed)
Also, wikipedia lists various alternative definitions, some of which place the focus on ideal factorization :
"every proper ideal factors into primes"
"every nonzero fractional ideal is invertible"
Those may be more to your liking.