Let $(\varphi_i)_{i \in I}$ be a sequence in $\mathcal H$. I want to show $(i) \Rightarrow (ii)$, where
$(i)$ The synthesis operator $T^{*}c = \sum_{i \in I} c_i x_i$ is well-defined for each $c = (c_i)_{i \in I} \in \ell_2(I)$ and maps $\ell_2(I)$ bijectively onto $\mathcal H$.
$(ii)$ There exists an orthonormal basis $(\psi_i)_{i \in I}$ for $\mathcal H$ and a bounded bijective operator $Q \in L(\mathcal H)$ such that $Q\psi_i = \varphi_i$ for every $i \in I$.
It's easy to see that if (i) holds, $(\varphi_i)_{i \in I} = (T^*e_i)_{i \in I}$, where $(e_i)_{i \in I}$ is the canonical base of $\ell_2(I)$. My idea is to use that if we have $(\kappa_i)_{i \in I}$ an orthonormal basis for $\mathcal H$, then $\mathcal H$ is isometrically isomorph to $\ell_2(I)$. The problem is that $\mathcal H$ might not be seperable and especially $I$ not countable, so I don't even know whether there exists an orthonormal basis with this cardinality.
Note that we don't use further equivalences such as $(ii)$ is equivalent to $(\varphi_i)_{i \in I}$ being a Riesz basis.