There is no way to differentiate the two groups, up to isomorphism.
Since $\gcd(5, 3) = 1$, we know that
$$\mathbb Z_{5} \times \mathbb Z_{3} \cong \mathbb Z_{15}$$
The set of elements are ordered pairs in $$\mathbb Z_5 \times \mathbb Z_3 = \{(0, 0), (0, 1), (0, 2), (1, 0), (1, 1), \ldots (2, 0), \ldots (5, 0), (5, 1), (5, 2)\}$$ You'd need to make a list 15 elements along the column headers, and the same along the row headers, just as you get when making a table for $\mathbb Z_{15}$. The element $(0,0)$ is the identity, and recall that the operation on $\mathbb Z_{5} \times \mathbb Z_{3}$ is component-wise addition, modulo 5 for the first term, mod 3 for the second term.
For example: $(1, 3) + (2, 2) = (3_{\text{ mod }5}, 2_{\text{ mod }3}) = (3, 2).$
Every of the 15 elements in $\mathbb Z_5\times \mathbb Z_3$ can be mapped to a unique element in $\mathbb Z_{15}$. So the Cayley tables will be identical, save for the name of each element.