In how many ways can you select $m\lt n$ squares on a $2\times n$ board such that exactly $n$ columns contain a selected square?
[Edit:]
From the lack of upvotes and the inquiring comment of a distinguished user I conclude that I should explain this perhaps overly laconic answer.
The OP wanted to prove the result by inclusion–exclusion. The number of ways to select $m$ squares on a $2\times n$ board such that at most $j$ particular columns contain a selected square is $\binom{2j}m$. By inclusion–exclusion, if there are $a_j$ ways to do something with at most $j$ particular objects, then there are
$$
\sum_{k=0}^n(-1)^k\binom nka_{n-k}
$$
ways to do it with exactly $n$ objects (where the binomial coefficient counts the number of ways of selecting $n-k$ particular ones of the $n$ objects). Putting this together yields the number of ways to select $m$ squares on a $2\times n$ board such that exactly $n$ columns contain a selected square:
$$
\sum_{k=0}^n(-1)^k\binom nk\binom{2n-2k}m\;.
$$
Since it's impossible to have exactly $n$ columns contain a selected square if less than $n$ squares are selected, this is $0$ for $m\lt n$, and thus in particular for $m=n-1$.