See this question for a general proof that the generic determinant is an irreducible polynomial. I will adapt the proof to this special case.
I will suppose $C$ is an integral domain (maybe you meant $\Bbb C$; that is a particular integral domain). Suppose $xy-zw=ab$ with $a,b\in C[x,y,z,w]$. Since the degree of $xy-zw$ in $x$ is $1$, one of $a,b$ must be of degree $1$ in $x$ and the other of degree $0$ (it does not contain $x$); by symmetry we may suppose $a$ is of degree $1$, say $a=px+q$ with $p,q\in C[y,z,w]$ and $p\neq0$. Now $b$ cannot contain either $z$ or $w$, lest the leading term in that variable produce a term in the product $pxb$ divisible by $xz$ respectively by $xw$ and which cannot be canceled by any other terms in the product $ab$, contradicting the fact that $ab=xy-zw$ contains no such terms. So $a$ is of degree $1$ in $z$ and $w$ as well as in $x$. Repeating the argument with $z$ in the place of $x$, we see that $b$ cannot contain any $y$ either (as $xy-zw$ has no terms divisible by $yz$), so it is a constant in $C$. But that constant divides the coefficients of all terms in $ab$, which means it is invertible, so the decomposition $ab$ is trivial. As a consequence $xy-zw$ is an irreducible polynomial in $C[y,z,w]$.
I used the fact that $C$ is an integral domain in the argument that the leading term of $b$ produces a (nonzero) term of $pxb$. I haven't tried to see if one can construct a ring with zero divisors over which $xy-zw$ factors non-trivially. But in any case question about factorisation usually suppose integral domains.