I can calculate the number with computer and read the digits, or I can say PowerMod[2, 100, 100]
in Mathematica, or I can even determine the digits myself, pencil-and-paper, by considering congruences modulo 4 and modulo 25 separately.
But if I determine the last digit first -- it's 6 -- and then set this congruent equation for the penultimate digit $y$:
$\frac{2^{100}-6}{10} \equiv y\ (mod\ 10)$
Which simplifies to $2^{99} - 3 \equiv 5\ y\ (mod\ 10)$, or $8 \equiv 5\ y + 3\ (mod\ 10)$, or $y \equiv 1\ (mod\ 2)$. This says this digit is odd. But how can I determine its exact value from here?
I wonder why sequential modulo 10 congruences don't yield a specific answer.