Suppose that $a,b$ are two orthogonal unit vectors in $\mathbb R^3$, want to find a unit vector $c$ orthogonal to both $a$ and $b$. And the matrix formed by using $a$, $b$, $c$ as row vectors has determinant 1.
One strategy would be to suppose that $c = (x_1, x_2, x_3)$, and write down three equations using given conditions. Then solve it. But this would be tedious. Are there any other methods?