There are a few possible forms for such a factorization:
- as a product of four (not necessarily distinct) linear factors with real coefficients,
- as a product of two quadratic factors with real coefficients, neither of which has real roots,
- as a product of two linear factors and a quadratic factor, all with real coefficients, such that the quadratic factor has no real roots.
Can you see why there are no other possibilities?
Now, note that $$x^4-2x^2+49=(x^2)^2-2x^2+1+48=(x^2-1)^2+48\ge 48$$ for all real $x,$ so that the polynomial has no real roots. This rules out the possibility of any linear factors with real coefficients, so the only possibility remaining is that we can factor it as a product of quadratics with real coefficients.
Set $$x^4-2x^2+49=(px^2+qx+r)(sx^2+tx+u)$$ with $p,s$ non-zero. We must have $ps=1.$ (Why?) Without loss of generality, we can assume that $p=s=1,$ because if not, we can factor out $p$ from the first quadratic and $s$ from the second to get $$x^4-2x^2+49=\left(x^2+\frac qpx+\frac rp\right)\left(x^2+\frac tsx+\frac us\right),$$ which is of the form $$x^4-2x^2+49=(x^2+q'x+r')(x^2+t'x+u').$$
Now, starting from $$x^4-2x^2+49=(x^2+qx+r)(x^2+tx+u),$$ expand the right-hand side and gather like terms. This will yield a system of $4$ equations in $4$ variables, which you should try to solve. If it has real solutions, we've succeeded! If not, it isn't possible.