There are a lots of questions (and several good explanations) on understanding the non-trivial outer automorphism of $S_6$. What I haven't seen, though, is a good explanation of why there are no such outer automorphisms for $n\neq 6$. Wikipedia makes a passing mention of this fact here.
In particular, they have this cryptic claim:
For every symmetric group other than $S_6$, there is no other conjugacy class of elements of order 2 with the same number of elements as the class of transpositions.
This seems like the natural thing to prove, given the knowledge that you can construct an outer automorphism of $S_6$ which takes transpositions to products of three transpositions (i.e. things like $(12)\mapsto (12)(34)(56)$.) Also, the second reason Wikipedia gives doesn't feel very intuitive to me.
My question, then, is how does one justify the original (quoted) statement above?
Here is the naive computation of sizes of conjugacy classes: We need to show that when $n, k\neq 6,3$ $$\frac{n!}{2^k k! (n-2k)!}\neq\frac{n!}{2(n-2)!},$$which is equivalent to $$2^k k!(n-2k)!\neq 2(n-2)!$$
What I want to say is something like, if $n{-}2$ is bigger than $k$, then there is always some factor on the RHS that doesn't appear in the LHS (except when it is a power of two). Will this type of analysis get me anywhere, or is there a better way to think about this?