Generally, when stating an equation with symbols such as $x$ or $r$,
you need to be very specific about what you actually mean by this equation.
For example, when we write
$$
\sec^2 x = 1 + \tan^2 x \qquad \text{for }-\frac\pi2 < x < \frac\pi2
$$
we mean that the expression on either side of the equation is a
function of $x$ over the entire open interval
$\left(-\frac\pi2, \frac\pi2\right)$.
In that case it is completely appropriate to differentiate both sides,
because the equation asserts that the left and right sides are
the exact same function of $x$ over some interval of the real number line,
so we can take the derivative of this function with respect to $x$
(provided we are inside that interval and provided the derivative exists).
Since it's the same function on either side of the equation,
all you get when you differentiate both sides is the derivative of
that function, which of course is equal to itself even if it happens
to be written a little differently in one place than in the other.
On the other hand, if we assert that $r$ and $k$ are known constants
and $x$ is unknown in
$$
e^{rx} = kx^2 - 1,
$$
we now have an equation that can be solved for $x$.
This particular equation is true for either one or
two distinct values of $x$ (depending on the values of $k$ and $r$);
other equations may have three solutions, $17$ solutions, or no solutions.
In the introduction of this equation, however,
there was never any implication that
$e^{rx}$ and $kx^2 - 1$ are the same function of $x$
over any open interval.
Since they are not the same function of $x$, there is no reason to
think that their derivatives will be equal,
so taking the derivatives of both sides and setting them equal is
not a legitimate thing to do.
In your question, you assert the equation
$$2^{(x+1)^2}=k+t_1(x^2+r),$$
then propose to "find $t_1$ in terms of $x$".
It is not 100% clear what the equation was supposed to mean,
even after clarifications in several comments,
but it seems likely that the equation was supposed to represent the
idea that $k$, $t_1$, and $r$ are known constants and that $x$
is an unknown value for which you wish to solve.
In that interpretation, you have something much like the example
$e^{rx} = kx^2 - 1$ above, that is, you do not have the same function
on two sides of an equation, and there is no justification for
setting the derivatives of both sides equal.
But let's suppose for a moment that you did actually mean that the
things on each side of the equation are the same function.
This clearly cannot be true if $k$, $r$, and $t_1$ are all constants,
but let's suppose that only $k$ and $r$ are given as constants.
Then it does make sense to say, let's solve for $t_1$ in terms of $x$,
provided that you mean that $t_1$ is a function of $x$
such that the entire right-hand side of the equation actually is the
same function of $x$ as the left-hand side of the equation.
But if you make that interpretation, then the assertion
$$
\frac{{\rm d} }{{\rm d}x}( k+t_1(x^2+r)) = t_1 \cdot 2x
$$
is simply wrong, because your interpretation of the problem
was that $t_1$ is a function of $x$, and therefore you cannot treat
$t_1$ as a constant when differentiating $t_1(x^2+r)$.
Instead, you need to apply the product rule.
The fact that going down your path ends up setting $t_1$ equal to some
non-constant function of $x$ indicates that it was not OK to ignore
the derivative of $t_1$ itself with respect to $x$.
Of course, there is a much simpler way to solve for $t_1$ in terms of
$x$, assuming $t_1$ is a function of $x$: just manipulate the original
equation (without taking derivatives) to isolate $t_1$.
Using standard techniques of high-school algebra to eliminate $k$
and then $x^2+r$ from the right-hand side of the equation, we get
$$
\frac{2^{(x+1)^2} - k}{x^2+r}=t_1,
$$
and that's $t_1$ expressed as a function of $x$ for any constants
$k$ and $r$.