(Crosspost from Overflow)
Given categories $\mathscr{C}$ and $\mathscr{D}$ and functors $F,G: \mathscr{C} \to \mathscr{D}$, we can form a bifunctor $$\mathscr{D}(F(\bullet), G(\bullet)): \mathscr{C}^\text{op} \times \mathscr{C} \to \mathsf{Set}$$ and the end of this functor is the set of natural transformations from $F \Rightarrow G$. (I guess we need $\mathscr{C}$ to be small in order to guarantee there is a set of such natural transformations, in general.)
Can I say anything about the coend? Is it some familiar thing?