$e$ is one of the most important numbers in our universe, it is everywhere. When I try to find out why the most common explanation is some reverse-engineered physics or finance problem. But these are just one off examples of why $e$ is important, they fall short of illuminating the origin of its significance. What I'm looking for is some fundamental definition of $e$ that explains it's significance and omnipresence, something akin to $\pi$ relating circumference and diameter.
Thanks, I hope I'm being clear.
EDIT*: A common saying is "$e$ is the most natural base." What does that mean?