Is the ring $K[a,b,c,d]/(ad-bc-1)$ a unique factorization domain?
I think this is a regular ring, so all of its localizations are UFDs by the Auslander–Buchsbaum theorem. However, I know there are Dedekind domains (which are regular; every local ring is a PID, so definitely UFD) that are not UFDs, so being a regular ring need not imply the ring is a UFD.
With the non-UFD Dedekind domains (at least the number rings), I can usually spot a non-unique factorization, but I don't see any here in this higher dimensional example.