In this site it has been proved that the harmonic number defined as:
$$\mathcal{H}_n=\sum_{k=1}^{n} \frac{1}{k}$$
is not an integer. One proof I have seen uses Bertrand's postulate while others use elementary number thoery. See here, here and here and I guess elsewhere. Of course Bertrand's postulate is a killer for this question. Now, how would one prove that the harmonic number of any order , namely,
$$\mathcal{H}_n^{(k)}= \sum_{i=1}^{n} \frac{1}{i^k}$$
is also not an integer ? I cannot think of something.