As noted by Bill Cook, there is a natural group to look at, which is the holomorph of $S_6$.
This works for any group.
More generally: if $N$ is a group, and $\varphi\colon H\to \mathrm{Aut}(N)$ is a group homomorphism, then this induces an action of $H$ on $N$ by the formula
$${}^hn = [\varphi(h)](n),$$
where "${}^hn$" means "the image of $n$ under the action of $h$". The formula makes sense because $\varphi(h)\in\mathrm{Aut}(N)$, so we can evaluate $\varphi(h)$ on $n$.
This action satisfies nice properties:
- ${}^h(nm) = {}^hn{}^hm$ for all $n,m\in N$, $h\in H$.
- ${}^k({}^hn) = {}^{kh}n$.
Given such a triple, $(N,H,\varphi)$, we can construct a $G$ that contains subgroups $\mathcal{N}$ and $\mathcal{H}$ isomorphic to $N$ and $H$, respectively, with $\mathcal{N}\triangleleft G$, $G=\langle\mathcal{N},\mathcal{H}\rangle=\mathcal{NH}$, and where for every $\mathfrak{h}\in \mathcal{H}$ and $\mathfrak{n}\in\mathcal{N}$, if $h\in H$ corresponds to $\mathfrak{h}$ and $n$ corresponds to $\mathfrak{n}$, then $\mathfrak{hnh}^{-1}$ corresponds to ${}^hn$. This is the semidirect product $N\rtimes_{\varphi}H$.
The underlying set of $N\rtimes_{\varphi}H$ is $N\times H$. The multiplication rule is
$$(n_1,h_1)\cdot (n_2,h_2) = \Bigl(n_1{}^hn_2,h_1h_2\Bigr).$$
I'll leave it to you to verify this group satisfies the properties given above, with
- $\mathcal{N} = \{ (n,1)\mid n\in N\}$;
- $\mathcal{H} = \{(1,h)\mid h\in H\}$.
Note that, indeed, we have:
$$(1,h)(n,1)(1,h)^{-1} = (1{}^hn,h)(1,h^{-1}) = ({}^hn,h)(1,h^{-1}) = ({}^hn{}^h1,hh^{-1}) = ({}^hn,1).$$
Conversely, if $G$ is a group, $N\triangleleft G$, $H\leq G$ are subgroups with $NH=\langle N,H\rangle = G$ and $N\cap H=\{1\}$, then for each $h\in H$ we have an automorphism of $N$ given by $n\mapsto hnh^{-1}={}^hn$; this yields a group homomorphism $\varphi\colon H\to \mathrm{Aut}(N)$, and it is easy to verify that the group $N\rtimes_{\varphi}H$ constructed as above is isomorphic to $G$.
Now, by taking $\varphi\colon\mathrm{Aut}(G)\to\mathrm{Aut}(G)$ being the identity, we can always construct the group $G\rtimes_{\mathrm{id}} \mathrm{Aut}(G)$, which is the aforementioned holomorph of $G$.