Solve in positive integers: $$(x+1)^n-x^n=p^m$$
$p$ is prime, $n\ge 2$. Seemingly Zsigmondy's Theorem and LTE won't work here.
Though you can tell (as suggested by user barto), using Zsigmondy, that $n=q$ is prime and $p\equiv 1\pmod q$ (since $\text{ord}_p (1+x^{-1})=q\mid p-1$ by FLT).
This is just a problem I've thought of (because I was solving diophantine equations of the form $x^n-y^n=p^m$ and the case $(x+1)^n-x^n=p^m$ is the only one that doesn't let me use Zsigmondy's Theorem directly to finish the problem) and I'm interested to hear a solution.
Zsigmondy's Theorem tells us that $x^n-y^n$
(if $(x,y)=1, x>y+1, (x,y,n)\neq (2,1,6), \lnot(n=2\wedge (x+y=2^l, l\in\mathbb N))$) has at least $d(n)$ different prime divisors ($d(n)$ -- number of $n$ divisors), which is impossible ($d(n)\ge 2$).
If $n=2\wedge (x+y=2^l, l\in\mathbb N)$, then we're left with $x-y=2^{m-l}$, which has infinitely many solutions, fully characterized by $(x,y)=(2^{m-l-1}+2^{l-1},2^{l-1}-2^{m-l-1})$.
If $(x,y)\neq 1$ or $x=y+1$, we're left with having to know how to solve diophantine equations of the form $(x+1)^n-x^n=p^m$.